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Article

Genetic Variation in Pattern Recognition Receptors and Adaptor Proteins Associated With Development of Chronic Q Fever.

The Journal of infectious diseases - 1 Sept 2015

Schoffelen Teske, Ammerdorffer Anne, Hagenaars Julia C J P, Bleeker-Rovers Chantal P, Wegdam-Blans Marjolijn C, Wever Peter C, Joosten Leo A B, van der Meer Jos W M, Sprong Tom, Netea Mihai G, van Deuren Marcel, van de Vosse Esther

Abstract excerpt

BACKGROUND: Q fever is an infection caused by Coxiella burnetii. Persistent infection (chronic Q fever) develops in 1%-5% of patients. We hypothesize that inefficient recognition of C. burnetii and/or activation of host-defense in individuals carrying genetic variants in pattern recognition receptors or adaptors would result in an increased likelihood to develop chronic Q fever. METHODS: Twenty-four...

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Source

Identifiers

PMID: 25722298
DOI: 10.1093/infdis/jiv113

Genes

TLR1
MYD88
NOD2
TIRAP
ITGAM
ITGAV
ITGB3
TLR2
TLR4
TLR6
TLR8

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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