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Article

Disturbed social behavior and motivation in rats selectively bred for deficient sensorimotor gating.

Schizophrenia research - 1 Dec 2007

Dieckmann Marco, Freudenberg Florian, Klein Steffen, Koch Michael, Schwabe Kerstin

Abstract excerpt

Deficient prepulse inhibition (PPI) of startle reflects disturbed sensorimotor gating found in certain neuropsychiatric disorders. We here tested whether rats selectively bred for deficient PPI are deteriorated in behavioral paradigms used to model negative symptoms of schizophrenia. Rats with low PPI preferred standard rat-chow when having the choice between lever-pressing for reward-pellets or freely available...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17855056
DOI: 10.1016/j.schres.2007.08.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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