Article
Vasopressin-deficient rats exhibit sensorimotor gating deficits that are reversed by subchronic haloperidol.
Biological psychiatry - 15 Sept 2001
Feifel D, Priebe K
Abstract excerpt
BACKGROUND: Brattleboro (BB) rats are Long Evans rats with a single base pair genetic mutation that impairs their ability to synthesize vasopressin, a neurotransmitter and neurohormone. Brattleboro rats are known to have deficits in memory, emotional reactivity, motivation, attention, and social recognition, abnormalities associated with schizophrenia. Prepulse inhibition (PPI) of the acoustic startle reflex...
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