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Article

Antipsychotic effects on prepulse inhibition in normal 'low gating' humans and rats.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Sept 2006

Swerdlow Neal R, Talledo Jo, Sutherland Ashley N, Nagy Derek, Shoemaker Jody M

Abstract excerpt

Development of new antipsychotics and their novel applications may be facilitated through the use of physiological markers in clinically normal individuals. Both genetic and neurochemical evidence suggests that reduced prepulse inhibition of startle (PPI) may be a physiological marker for individuals at-risk for schizophrenia, and the ability of antipsychotics to normalize PPI may reflect properties linked to...

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Identifiers

PMID: 16482083
DOI: 10.1038/sj.npp.1301043

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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