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Article

Selective breeding for deficient sensorimotor gating is accompanied by increased perseveration in rats.

Neuroscience - 7 Sept 2007

Freudenberg F, Dieckmann M, Winter S, Koch M, Schwabe K

Abstract excerpt

Prepulse inhibition (PPI) of the acoustic startle response is a measure of sensorimotor gating that is deficient in some neuropsychiatric disorders, such as schizophrenia and Tourette's syndrome. Experimentally induced PPI deficits in rats are regarded as endophenotype to study the biological mechanisms and therapeutic strategies of these disorders. We have recently shown that selectively breeding rats for high...

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Source

Identifiers

PMID: 17693035
DOI: 10.1016/j.neuroscience.2007.06.034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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