Selective breeding for deficient sensorimotor gating is accompanied by increased perseveration in rats.

doi:10.1016/j.neuroscience.2007.06.034

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Selective breeding for deficient sensorimotor gating is accompanied by increased perseveration in rats.

Neuroscience - 7 Sept 2007

Freudenberg F, Dieckmann M, Winter S, Koch M, Schwabe K

Abstract excerpt

Prepulse inhibition (PPI) of the acoustic startle response is a measure of sensorimotor gating that is deficient in some neuropsychiatric disorders, such as schizophrenia and Tourette's syndrome. Experimentally induced PPI deficits in rats are regarded as endophenotype to study the biological mechanisms and therapeutic strategies of these disorders. We have recently shown that selectively breeding rats for high...

Topics

Animals
Breeding
Cognition Disorders
Conditioning, Operant
Disease Models, Animal
Female
Genetic Predisposition to Disease
Learning Disabilities
Male
Maze Learning
Memory Disorders
Mental Disorders
Neural Inhibition
Neuropsychological Tests
Rats
Rats, Wistar
Reflex, Abnormal
Reflex, Startle

Source

Open in PubMed

Identifiers

PMID: 17693035
DOI: 10.1016/j.neuroscience.2007.06.034

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics