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Article

The association of Sam68 with Vav1 contributes to tumorigenesis.

Cellular signalling - 1 Dec 2007

Lazer Galit, Pe'er Liron, Schapira Vered, Richard Stéphane, Katzav Shulamit

Abstract excerpt

Vav1 functions in the hematopoietic system as a specific GDP/GTP nucleotide exchange factor regulated by tyrosine phosphorylation. An intact C-terminal SH3 domain of Vav1 (Vav1SH3C) was shown to be necessary for Vav1-induced transformation, yet the associating protein(s) necessary for this activity have not yet been identified. Using a proteomics approach, we identified Sam68 as a Vav1SH3C-associating protein....

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Identifiers

PMID: 17855053
DOI: 10.1016/j.cellsig.2007.07.022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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