Inhibition of HIV replication by dominant negative mutants of Sam68, a functional homolog of HIV-1 Rev.

doi:10.1038/9479

Article

Inhibition of HIV replication by dominant negative mutants of Sam68, a functional homolog of HIV-1 Rev.

Nature medicine - 1 Jun 1999

Reddy T R, Xu W, Mau J K, Goodwin C D, Suhasini M, Tang H, Frimpong K, Rose D W, Wong-Staal F

Abstract excerpt

The HIV-1 Rev protein facilitates the nuclear export of mRNA containing the Rev response element (RRE) through binding to the export receptor CRM-1. Here we show that a cellular nuclear protein, Sam68 (Src-associated protein in mitosis), specifically interacts with RRE and can partially substitute for as well as synergize with Rev in RRE-mediated gene expression and virus replication. Differential sensitivity to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Inhibition of HIV replication by dominant negative mutants of Sam68, a functional homolog of HIV-1 Rev.

Abstract excerpt

Topics

Inhibition of HIV replication by dominant negative mutants of Sam68, a functional homolog of HIV-1 Rev.

Abstract excerpt

Topics

Related research