Article
Effect of proline rich domain of an RNA-binding protein Sam68 in cell growth process, death and B cell signal transduction.
Chinese medical journal - 20 Sept 2006
Li Qing-hua, Fan Tian-xue, Pang Tian-xiang, Yuan Wen-su, Han Zhong-chao
Abstract excerpt
BACKGROUND: Sam68 plays an important role as a multiple functional RNA binding nuclear protein in cell cycle progress, RNA usage, signal transduction, and tyrosine phosphorylation by Src during mitosis. However, its precise impact on these essential cellular functions remains unclear. The purpose of this study is to further elucidate Sam68 functions in RNA metabolism, signal transduction regulation of cell growth...
Topics
- Adaptor Proteins, Signal Transducing
- Animals
- B-Lymphocytes
- Binding Sites
- Blotting, Western
- Cell Cycle
- Cell Death
- Cell Growth Processes
- Cell Line, Tumor
- Culture Media, Serum-Free
- Mutation
- Phosphorylation
- Proline
- RNA-Binding Proteins
- Receptors, Antigen, B-Cell
- Signal Transduction
- Tyrosine