Article
Genetic variants in the H2AFX promoter region are associated with risk of sporadic breast cancer in non-Hispanic white women aged <or=55 years.
Breast cancer research and treatment - 1 Jul 2008
Lu Jiachun, Wei Qingyi, Bondy Melissa L, Brewster Abenaa M, Bevers Therese B, Yu Tse-Kuan, Buchholz Thomas A, Meric-Bernstam Funda, Hunt Kelly K, Singletary S Eva, Wang Li-E
Abstract excerpt
The histone protein family member X (H2AFX) is important in maintaining chromatin structure and genetic stability. Genetic variants in H2AFX may alter protein functions and thus cancer risk. In this case-control study, we genotyped four common single nucleotide polymorphisms (i.e., -1654A > G [rs643788], -1420G > A [rs8551], and -1187T > C [rs7759] in the H2AFX promoter region and 1057C > T [rs7350] in the 3'...
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