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Polymorphisms and haplotypes of the NBS1 gene are associated with risk of sporadic breast cancer in non-Hispanic white women <or=55 years.

Carcinogenesis - 1 Nov 2006

Lu Jiachun, Wei Qingyi, Bondy Melissa L, Li Donghui, Brewster Abenaa, Shete Sanjay, Yu Tse-Kuan, Sahin Aysegul, Meric-Bernstam Funda, Hunt Kelly K, Singletary S Eva, Ross Merrick I, Wang Li-E

Abstract excerpt

DNA double-strand breaks (DSBs) may lead to genomic instability and cancer if unrepaired. Nijmegen breakage syndrome 1 (NBS1) protein is one of the key proteins that participates in recognition and repair of DSBs in humans. We hypothesized that polymorphisms of NBS1 are associated with breast cancer risk. We selected three NBS1 haplotype-tagging polymorphisms (i.e. 924T>C, 8360G>C and 30537G>C) to represent all...

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PMID: 16714331
DOI: 10.1093/carcin/bgl077

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Polymorphisms and haplotypes of the NBS1 gene are associated with risk of sporadic breast cancer in non-Hispanic white women <or=55 years.PMID 16714331Read ↗

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