Sex- and subtype-specific analysis of H2AFX polymorphisms in non-Hodgkin lymphoma.

doi:10.1371/journal.pone.0074619

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Article

Sex- and subtype-specific analysis of H2AFX polymorphisms in non-Hodgkin lymphoma.

PloS one - 1 Jan 2013

Bretherick Karla L, Schuetz Johanna M, Morton Lindsay M, Purdue Mark P, Conde Lucia, Gallagher Richard P, Connors Joseph M, Gascoyne Randy D, Berry Brian R, Armstrong Bruce, Kricker Anne, Vajdic Claire M, Grulich Andrew, Hjalgrim Henrik, Smedby Karin E, Skibola Christine F, Rothman Nathaniel, Spinelli John J, Brooks-Wilson Angela R

Abstract excerpt

H2AFX encodes a histone variant involved in signaling sites of DNA damage and recruiting repair factors. Genetic variants in H2AFX may influence risk of non-Hodgkin lymphoma (NHL), a heterogeneous group of lymphoid tumors that are characterized by chromosomal translocations. We previously reported that rs2509049, a common variant in the promoter of H2AFX, was associated with risk for NHL in the British Columbia...

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PMID: 24069324
DOI: 10.1371/journal.pone.0074619
PMCID: PMC3775730

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