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Article

Antiviral and Mutagenic Effects of APOBEC Deaminases A3C, A3D, and A3H in a Hepatitis B Virus Model.

Biochemistry. Biokhimiia - 1 Feb 2026

Karandashov Ivan V, Brezgin Sergey A, Ponomareva Natalia I, Tikhonov Andrey S, Chulanov Vladimir P, Kostyushev Dmitry S, Kostyusheva Anastasiya P

Abstract excerpt

Hepatitis B virus (HBV) infects human hepatocytes, causing acute or chronic liver infection. Chronic HBV infection leads to progressive liver damage, potentially resulting in cirrhosis or hepatocellular carcinoma. One promising antiviral strategy involves activating cytidine deaminases of the APOBEC/AID family, which could induce mutational degradation of HBV. Using a CRISPRa-based transcriptional activation...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41843845
DOI: 10.1134/S0006297925603326

Genes

APOBEC3C
APOBEC3D
APOBEC3H

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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