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Article

The N-terminal coiled-coil domain of the cytohesin/ARNO family of guanine nucleotide exchange factors interacts with Galphaq.

Molecular and cellular biochemistry - 1 Dec 2007

Laroche Geneviève, Giguère Patrick M, Dupré Emilie, Dupuis Gilles, Parent Jean-Luc

Abstract excerpt

Cytohesins are guanine-nucleotide exchange factors (GEF) for the Arf family of GTPases. One member of the Arf family, ARF6, plays an active role in the intracellular trafficking of G protein-coupled receptors. We have previously reported that Galphaq signaling leads to the activation of ARF6, possibly through a direct interaction with cytohesin-2/ARNO. Here, we report that Galphaq can directly interact with...

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Source

Identifiers

PMID: 17846866
DOI: 10.1007/s11010-007-9564-9

Genes

ARF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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