Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Activation of Ras-dependent signaling pathways by G(14) -coupled receptors requires the adaptor protein TPR1.

Journal of cellular biochemistry - 1 Nov 2012

Kwan Dawna H T, Yung Lisa Y, Ye Richard D, Wong Yung H

Abstract excerpt

Many G(q) -coupled receptors mediate mitogenic signals by stimulating extracellular signal-regulated protein kinases (ERKs) that are typically regulated by the small GTPase Ras. Recent studies have revealed that members of the Gα(q) family may possess the ability to activate Ras/ERK by interacting with the adaptor protein tetratricopeptide repeat 1 (TPR1). Within the Gα(q) family, the highly promiscuous Gα(14)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Vesicular Transport
Share to GTP-Binding Protein alpha Subunits, Gq-G11

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hep G2 Cells

Share to Heterotrimeric GTP-Binding Proteins

Share to I-kappa B Kinase

Share to JNK Mitogen-Activated Protein Kinases

Share to Phospholipase C beta

Share to SOS1 Protein

Source

Identifiers

PMID: 22711498
DOI: 10.1002/jcb.24225

Genes

SOS1
SOS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activation of Ras-dependent signaling pathways by G(14) -coupled receptors requires the adaptor protein TPR1.PMID 22711498Read ↗

Galpha16 activates Ras by forming a complex with tetratricopeptide repeat 1 (TPR1) and Son of Sevenless (SOS).Semantic proximity Read ↗

An Insight into GPCR and G-Proteins as Cancer DriversSemantic proximity Read ↗

Receptor tyrosine kinases activate heterotrimeric G proteins via phosphorylation within the interdomain cleft of GαiSemantic proximity Read ↗

The N-terminal coiled-coil domain of the cytohesin/ARNO family of guanine nucleotide exchange factors interacts with Galphaq.Semantic proximity Read ↗

Direct Coupling of a Seven-Transmembrane-Span Receptor to a Gαi G-Protein Regulatory Motif Complex.Semantic proximity Read ↗

Membrane interactions of G proteins and other related proteins.Semantic proximity Read ↗

G protein-coupled receptors as promising cancer targets.Semantic proximity Read ↗

The GS Domain of the Transforming Growth Factor-β Type-I Receptor Is Important in Signal TransductionSemantic proximity Read ↗

Heterotrimeric G Proteins and Apoptosis: Intersecting Signaling Pathways Leading to Context Dependent PhenotypesSemantic proximity Read ↗

Agonist- and protein kinase C-induced phosphorylation have similar functional consequences for gastrin-releasing peptide receptor signaling via Gq.Semantic proximity Read ↗

Mutant alpha-subunit of the G protein G12 activates proliferation and inhibits differentiation of 3T3-F442A preadipocytes.Semantic proximity Read ↗

Protease-activated receptor 1 (PAR1) coupling to G(q/11) but not to G(i/o) or G(12/13) is mediated by discrete amino acids within the receptor second intracellular loop.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.