Article
The guanine nucleotide exchange factor ARNO mediates the activation of ARF and phospholipase D by insulin.
BMC cell biology - 11 Sept 2003
Li Hai-Sheng, Shome Kuntala, Rojas Raúl, Rizzo Megan A, Vasudevan Chandrasekaran, Fluharty Eric, Santy Lorraine C, Casanova James E, Romero Guillermo
Abstract excerpt
BACKGROUND: Phospholipase D (PLD) is involved in many signaling pathways. In most systems, the activity of PLD is primarily regulated by the members of the ADP-Ribosylation Factor (ARF) family of GTPases, but the mechanism of activation of PLD and ARF by extracellular signals has not been fully e...
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