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Article

The guanine nucleotide exchange factor ARNO mediates the activation of ARF and phospholipase D by insulin.

BMC cell biology - 11 Sept 2003

Li Hai-Sheng, Shome Kuntala, Rojas Raúl, Rizzo Megan A, Vasudevan Chandrasekaran, Fluharty Eric, Santy Lorraine C, Casanova James E, Romero Guillermo

Abstract excerpt

BACKGROUND: Phospholipase D (PLD) is involved in many signaling pathways. In most systems, the activity of PLD is primarily regulated by the members of the ADP-Ribosylation Factor (ARF) family of GTPases, but the mechanism of activation of PLD and ARF by extracellular signals has not been fully established. Here we tested the hypothesis that ARF-guanine nucleotide exchange factors (ARF-GEFs) of the cytohesin/ARNO...

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Identifiers

PMID: 12969509
DOI: 10.1186/1471-2121-4-13
PMCID: PMC212319

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Source receipt: pubmed, retrieved 7 Sept 2026.

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