Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of APOE-epsilon4 in longitudinal cognitive decline: MacArthur Studies of Successful Aging.

Neurology - 8 Apr 2003

Bretsky P, Guralnik J M, Launer L, Albert M, Seeman T E

Abstract excerpt

BACKGROUND: While a genetic risk factor for late-onset AD, the effects of the epsilon4 allele of the APOE gene on cognitive functioning more generally remain unclear. OBJECTIVE: To assess the role of the epsilon4 allele of the APOE gene in longitudinal cognitive decline. METHODS: Multiple measures of cognitive function were assessed longitudinally in the MacArthur Successful Aging Study, a population-based cohort...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoprotein E4
Share to Apolipoproteins E
Share to Black or African American

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Black People

Share to Cognition Disorders

Share to Demography

Share to Longitudinal Studies

Share to United States

Source

Identifiers

PMID: 12682309
DOI: 10.1212/01.wnl.0000055875.26908.24

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of APOE-epsilon4 in longitudinal cognitive decline: MacArthur Studies of Successful Aging.PMID 12682309Read ↗

The apolipoprotein E epsilon 4 allele and decline in different cognitive systems during a 6-year period.Semantic proximity Read ↗

Longitudinal Modeling of Age-Related Memory Decline and the<i>APOE</i>ε4 EffectSemantic proximity Read ↗

The APOE epsilon4 allele is associated with decline on delayed recall performance in community-dwelling older adults.Semantic proximity Read ↗

APOE genotype and cognitive decline in a middle-aged cohort.Semantic proximity Read ↗

APOE-epsilon4 is associated with memory decline in cognitively impaired elderly.Semantic proximity Read ↗

Neuropsychological function and apolipoprotein E genotype in the preclinical detection of Alzheimer's disease.Semantic proximity Read ↗

Apolipoprotein epsilon4 allele status, depressive symptoms, and cognitive decline in middle-aged and elderly persons without dementia.Semantic proximity Read ↗

The APOE epsilon4 allele is associated with incident mild cognitive impairment among community-dwelling older persons.Semantic proximity Read ↗

A gender difference in the association between APOE genotype and age-related cognitive decline.Semantic proximity Read ↗

Cognitive domain decline in healthy apolipoprotein E epsilon4 homozygotes before the diagnosis of mild cognitive impairment.Semantic proximity Read ↗

Impact of APOE epsilon4 on the cognitive performance of a sample of non-demented Puerto Rican nonagenarians.Semantic proximity Read ↗

Apolipoprotein E epsilon 4 affects new learning in cognitively normal individuals at risk for Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.