The apolipoprotein E epsilon 4 allele and decline in different cognitive systems during a 6-year period.

doi:10.1001/archneur.59.7.1154

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Article

The apolipoprotein E epsilon 4 allele and decline in different cognitive systems during a 6-year period.

Archives of neurology - 1 Jul 2002

Wilson Robert S, Schneider Julie A, Barnes Lisa L, Beckett Laurel A, Aggarwal Neelum T, Cochran Elizabeth J, Berry-Kravis Elizabeth, Bach Julie, Fox Jacob H, Evans Denis A, Bennett David A

Abstract excerpt

CONTEXT: Impairment of episodic memory is an early and defining feature of Alzheimer disease (AD). The apolipoprotein E (APOE) epsilon 4 allele is known to influence risk of AD but it has been difficult to establish whether it affects episodic memory differently from other cognitive functions. OBJECTIVE: To examine the association of epsilon 4 with decline in different cognitive systems. DESIGN: Longitudinal...

Topics

Aged
Alleles
Alzheimer Disease
Apolipoproteins E
Cognition
Female
Humans
Longitudinal Studies
Male
Memory
Risk
United States

Source

Open in PubMed

Identifiers

PMID: 12117364
DOI: 10.1001/archneur.59.7.1154

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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