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Article

Memory complaints and APOE-epsilon4 accelerate cognitive decline in cognitively normal elderly.

Neurology - 26 Dec 2001

Dik M G, Jonker C, Comijs H C, Bouter L M, Twisk J W, van Kamp G J, Deeg D J

Abstract excerpt

OBJECTIVE: To investigate to what extent subjective memory complaints and APOE-epsilon4 allele carriage predict future cognitive decline in cognitively intact elderly persons, by evaluating both their separate and combined effects. METHODS: We selected 1,168 subjects from the population-based Longitudinal Aging Study Amsterdam who were 62 to 85 years of age and had no obvious cognitive impairment at baseline...

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Source

Identifiers

PMID: 11756600
DOI: 10.1212/wnl.57.12.2217

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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