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Article

An investigation of the effects of lipid-lowering medications: genome-wide linkage analysis of lipids in the HyperGEN study.

BMC genetics - 10 Sept 2007

Wu Jun, Province Michael A, Coon Hilary, Hunt Steven C, Eckfeldt John H, Arnett Donna K, Heiss Gerardo, Lewis Cora E, Ellison R Curtis, Rao Dabeeru C, Rice Treva, Kraja Aldi T

Abstract excerpt

BACKGROUND: Use of anti-hyperlipidemic medications compromises genetic analysis because of altered lipid profiles. We propose an empirical method to adjust lipid levels for medication effects so that the adjusted lipid values substitute the unmedicated lipid values in the genetic analysis. RESULTS: Published clinical trials were reviewed for HMG-CoA reductase inhibitors and fibric acid derivatives as mono-drug...

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Identifiers

PMID: 17845730
DOI: 10.1186/1471-2156-8-60
PMCID: PMC2045675

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