Article
A genome-wide study of lipid response to fenofibrate in Caucasians: a combined analysis of the GOLDN and ACCORD studies.
Pharmacogenetics and genomics - 1 Jul 2016
Irvin Marguerite R, Rotroff Daniel M, Aslibekyan Stella, Zhi Degui, Hidalgo Bertha, Motsinger-Reif Alison, Marvel Skylar, Srinivasasainagendra Vinodh, Claas Steven A, Buse John B, Straka Robert J, Ordovas Jose M, Borecki Ingrid B, Guo Xiuqing, Chen Ida Y D, Rotter Jerome I, Wagner Michael J, Arnett Donna K
Abstract excerpt
BACKGROUND: Fibrates are commonly prescribed for hypertriglyceridemia, but they also lower LDL cholesterol and increase HDL cholesterol. Large interindividual variations in lipid response suggest that some patients may benefit more than others and genetic studies could help identify such patients. METHODS: We carried out the first genome-wide association study of lipid response to fenofibrate using data from two...
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