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Assessing long-term pleiotropic effects of potential novel triglyceride-lowering medications using variants identified by Mendelian randomization

2025-03-10

Abstract excerpt

Drugs targeting triglyceride (TG)-associated genes have the potential to improve cardiovascular outcomes. However, we know little regarding the potential additional benefits or deleterious effects of such targeting. As such, in ancestry-specific cohorts of European ancestry (EA) and African ancestry (AA) at Vanderbilt (BioVU), we used PheWAS to test associations between measured TG levels and validated variants pr...

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Literature Corpus work
0dbdbb68-73ae-5d56-b493-930bc764cd43
DOI
10.1101/2025.03.07.25323588
Open publication

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Assessing long-term pleiotropic effects of potential novel triglyceride-lowering medications using variants identified by Mendelian randomizationDOI 10.1101/2025.03.07.25323588
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