Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Causal effects of lipid-lowering therapies on aging-related outcomes and risk of cancers: a drug-target Mendelian randomization study.

Aging - 19 Dec 2023

Chen Han, Tang Xinyu, Su Wei, Li Shuo, Yang Ruoyun, Cheng Hong, Zhang Guoxin, Zhou Xiaoying

Abstract excerpt

BACKGROUND: Despite the widespread use of statins, newer lipid-lowering drugs have been emerging. It remains unclear how the long-term use of novel lipid-lowering drugs affects the occurrence of cancers and age-related diseases. METHODS: A drug-target Mendelian randomization study was performed. Genetic variants of nine lipid-lowering drug-target genes (HMGCR, PCKS9, NPC1L1, LDLR, APOB, CETP, LPL, APOC3, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Angiopoietin-Like Protein 3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apolipoproteins B

Share to Cholesterol, LDL

Share to Diabetes Mellitus, Type 2

Share to Hypolipidemic Agents

Share to Mendelian Randomization Analysis

Share to Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 38127052
DOI: 10.18632/aging.205347
PMCID: PMC10781452

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Causal effects of lipid-lowering therapies on aging-related outcomes and risk of cancers: a drug-target Mendelian randomization study.PMID 38127052Read ↗

Causal association between lipid-lowering drugs and cancers: A drug target Mendelian randomization study.Semantic proximity Read ↗

Causal effects of lipid-lowering drug targets on psychiatric disorders: A drug-target Mendelian randomization study.Semantic proximity Read ↗

Metabolomic signatures of lipid-modifying therapies using drug target Mendelian randomizationSemantic proximity Read ↗

Association of lipid-lowering drugs with osteoarthritis outcomes from a drug-target Mendelian randomization study.Semantic proximity Read ↗

Causal relationship between lipid-lowering drugs and ovarian cancer, cervical cancer: a drug target mendelian randomization study.Semantic proximity Read ↗

Characterising metabolomic signatures of lipid-modifying therapies through drug target mendelian randomisationSemantic proximity Read ↗

Predicting the effect of statins on cancer risk using genetic variants from a Mendelian randomization study in the UK Biobank.Semantic proximity Read ↗

Genetic association analysis of lipid-lowering drug target genes in chronic kidney disease.Semantic proximity Read ↗

Low‐density lipoprotein cholesterol and lifespan: A Mendelian randomization studySemantic proximity Read ↗

Causal association of blood lipids with all-cause and cause-specific mortality risk: a Mendelian randomization studySemantic proximity Read ↗

Validation of lipid-related therapeutic targets for coronary heart disease prevention using human geneticsSemantic proximity Read ↗

Genetically-predicted life-long lowering of low-density lipoprotein cholesterol is associated with decreased frailty: A Mendelian randomization study in UK biobankSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.