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Article

Comprehensive assessment of the causal effects and metabolite mediators of glucose-lowering drug targets on cardio-renal-liver-metabolic health.

Metabolism: clinical and experimental - 1 Aug 2025

Huang Haozhang, Ruan Huangtao, Lu Xiaozhao, Chen Shiqun, Chen Jiyan, Tan Ning, Pan Wei, Liu Jin, Liu Yong

Abstract excerpt

AIMS: To investigate the relationship between glucose-lowering medications and cardio-renal-liver-metabolic (CRLM) health. METHODS: Two-sample Mendelian randomization (MR) was applied to assess the causal relationships between seven classes of glucose-lowering drugs and CRLM health outcomes. Genetic proxies for drug exposure were identified as cis-acting single nucleotide polymorphisms in the drug target genes,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40320164
DOI: 10.1016/j.metabol.2025.156276

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