Article
Polyunsaturated fatty acids influence synaptojanin localization to regulate synaptic vesicle recycling.
Molecular biology of the cell - 1 Mar 2008
Marza Esther, Long Toni, Saiardi Adolfo, Sumakovic Marija, Eimer Stefan, Hall David H, Lesa Giovanni M
Abstract excerpt
The lipid polyunsaturated fatty acids are highly enriched in synaptic membranes, including synaptic vesicles, but their precise function there is unknown. Caenorhabditis elegans fat-3 mutants lack long-chain polyunsaturated fatty acids (LC-PUFAs); they release abnormally low levels of serotonin and acetylcholine and are depleted of synaptic vesicles, but the mechanistic basis of these defects is unclear. Here we...
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