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Article

Endophilin is required for synaptic vesicle endocytosis by localizing synaptojanin.

Neuron - 13 Nov 2003

Schuske Kimberly R, Richmond Janet E, Matthies Dawn Signor, Davis Warren S, Runz Steffen, Rube Daniel A, van der Bliek Alexander M, Jorgensen Erik M

Abstract excerpt

Endophilin is a membrane-associated protein required for endocytosis of synaptic vesicles. Two models have been proposed for endophilin: that it alters lipid composition in order to shape membranes during endocytosis, or that it binds the polyphosphoinositide phosphatase synaptojanin and recruits this phosphatase to membranes. In this study, we demonstrate that the unc-57 gene encodes the Caenorhabditis elegans...

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PMID: 14622579
DOI: 10.1016/s0896-6273(03)00667-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Click a neighbor to travelStep 1 · 12 closest

Endophilin is required for synaptic vesicle endocytosis by localizing synaptojanin.PMID 14622579Read ↗

Synaptojanin is recruited by endophilin to promote synaptic vesicle uncoating.Semantic proximity Read ↗

UNC-80 and the NCA ion channels contribute to endocytosis defects in synaptojanin mutants.Semantic proximity Read ↗

Mutations in synaptojanin disrupt synaptic vesicle recycling.Semantic proximity Read ↗

Endophilin mutations block clathrin-mediated endocytosis but not neurotransmitter release.Semantic proximity Read ↗

Essential role of endophilin A in synaptic vesicle budding at the Drosophila neuromuscular junction.Semantic proximity Read ↗

UNC-41/stonin functions with AP2 to recycle synaptic vesicles in Caenorhabditis elegans.Semantic proximity Read ↗

Defective recycling of synaptic vesicles in synaptotagmin mutants of Caenorhabditis elegans.Semantic proximity Read ↗

Polyunsaturated fatty acids influence synaptojanin localization to regulate synaptic vesicle recycling.Semantic proximity Read ↗

UNC-11, a Caenorhabditis elegans AP180 homologue, regulates the size and protein composition of synaptic vesicles.Semantic proximity Read ↗

The EARP Complex and its Interactor EIPR-1 are Required for Cargo Sorting to Dense-Core VesiclesSemantic proximity Read ↗

UNC-13 is required for synaptic vesicle fusion in C. elegans.Semantic proximity Read ↗

Endophilin is critically required for synapse formation and function in Drosophila melanogaster.Semantic proximity Read ↗

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