The calcium-sensing receptor regulates plasma membrane calcium adenosine triphosphatase isoform 2 activity in mammary epithelial cells: a mechanism for calcium-regulated calcium transport into milk.

doi:10.1210/en.2007-0850

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Article

The calcium-sensing receptor regulates plasma membrane calcium adenosine triphosphatase isoform 2 activity in mammary epithelial cells: a mechanism for calcium-regulated calcium transport into milk.

Endocrinology - 1 Dec 2007

VanHouten Joshua N, Neville Margaret C, Wysolmerski John J

Abstract excerpt

The calcium-sensing receptor (CaR) regulates transepithelial calcium transport into milk by mammary epithelial cells. Using a genome-wide screening strategy, we identified the plasma membrane calcium ATPase isoform 2 (PMCA2) as a potential downstream target of the CaR. We show that PMCA2 expression in the mouse mammary gland increases during lactation and that PMCA2 is localized solely to the apical plasma...

Topics

Animals
Biological Transport
Blotting, Western
Calcium
Cells, Cultured
Epithelial Cells
Female
Fluorescent Antibody Technique
Gadolinium
Isoenzymes
Lactation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mammary Glands, Animal

Mice

Mice, Inbred BALB C

Microscopy, Immunoelectron

Milk

Milk Proteins

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 17823248
DOI: 10.1210/en.2007-0850
PMCID: PMC7108505

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