Article

The calcium pump PMCA4b promotes epithelial cell polarization and lumen formation

2024-01-21

Abstract excerpt

Loss of epithelial cell polarity and tissue disorganization are hallmarks of carcinogenesis, in which Ca 2+ signaling plays a significant role. Here we demonstrate that the plasma membrane Ca 2+ pump PMCA4 (ATP2B4) is downregulated in luminal breast cancer, and this is associated with shorter relapse-free survival in patients with luminal A and B1 subtype tumors. Using the MCF-7 breast cancer cell model we show...

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Literature Corpus work: 04fc1a9c-b9bb-5e48-b92e-7066b01a082b
DOI: 10.1101/2024.01.20.576436

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