Phenotypes of SERCA and PMCA knockout mice.

doi:10.1016/j.bbrc.2004.07.156

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Article

Phenotypes of SERCA and PMCA knockout mice.

Biochemical and biophysical research communications - 1 Oct 2004

Prasad Vikram, Okunade Gbolahan W, Miller Marian L, Shull Gary E

Abstract excerpt

P-type Ca2+-ATPases of the sarco(endo)plasmic reticulum (SERCAs) and plasma membrane (PMCAs) are responsible for maintaining the Ca2+ gradients across cellular membranes that are required for regulation of Ca2+-mediated signaling and other biological processes. Gene-targeting studies of SERCA isoforms 1, 2, and 3 and PMCA isoforms 1, 2, and 4 have confirmed some of the general functions proposed for these pumps,...

Topics

Animals
Calcium Signaling
Calcium-Transporting ATPases
Carcinoma, Squamous Cell
Cation Transport Proteins
Deafness
Mice
Mice, Knockout
Phenotype
Plasma Membrane Calcium-Transporting ATPases
Sarcoplasmic Reticulum Calcium-Transporting ATPases
Sperm Motility

Source

Open in PubMed

Identifiers

PMID: 15336967
DOI: 10.1016/j.bbrc.2004.07.156

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