Article
Distinct phenotypes among plasma membrane Ca2+-ATPase knockout mice.
Annals of the New York Academy of Sciences - 1 Mar 2007
Prasad Vikram, Okunade Gbolahan, Liu Li, Paul Richard J, Shull Gary E
Abstract excerpt
Ca2+ gradients across the plasma membrane, required for Ca2+ homeostasis and signaling, are maintained in part by plasma membrane Ca2+-ATPase (PMCA) isoforms 1-4. Gene targeting has been used to analyze the functions of PMCA1, PMCA2, and PMCA4 in mice. PMCA1 null mutant embryos die during the preimplantation stage, and loss of a single copy of the PMCA1 gene contributes to apoptosis in vascular smooth muscle....
Topics
- Animals
- Calcium-Transporting ATPases
- Cell Membrane
- Isoenzymes
- Mice
- Phenotype
- RNA, Messenger