Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2 impairs calcium transport into milk.

The Journal of biological chemistry - 8 Oct 2004

Reinhardt Timothy A, Lippolis John D, Shull Gary E, Horst Ronald L

Abstract excerpt

The means by which calcium is transported into the milk produced by mammary glands is a poorly understood process. One hypothesis is that it occurs during exocytosis of secretory products via the Golgi pathway, consistent with the observation that the SPCA1 Ca2+-ATPase, which is expressed in the Golgi, is induced in lactating mammary tissue. However, massive up-regulation of the PMCA2bw plasma membrane...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium-Transporting ATPases
Share to Exocytosis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Golgi Apparatus

Share to Intracellular Membranes

Share to Lactose

Share to Mammary Glands, Animal

Share to Microsomes

Share to Plasma Membrane Calcium-Transporting ATPases

Source

Identifiers

PMID: 15302868
DOI: 10.1074/jbc.M407788200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Null mutation in the gene encoding plasma membrane Ca2+-ATPase isoform 2 impairs calcium transport into milk.PMID 15302868Read ↗

Distinct phenotypes among plasma membrane Ca2+-ATPase knockout mice.Semantic proximity Read ↗

The calcium-sensing receptor regulates plasma membrane calcium adenosine triphosphatase isoform 2 activity in mammary epithelial cells: a mechanism for calcium-regulated calcium transport into milk.Semantic proximity Read ↗

Phenotypes of SERCA and PMCA knockout mice.Semantic proximity Read ↗

The PMCA pumps in genetically determined neuronal pathologies.Semantic proximity Read ↗

Loss of the Atp2c1 secretory pathway Ca(2+)-ATPase (SPCA1) in mice causes Golgi stress, apoptosis, and midgestational death in homozygous embryos and squamous cell tumors in adult heterozygotes.Semantic proximity Read ↗

ZnT4 (SLC30A4)-null ("lethal milk") mice have defects in mammary gland secretion and hallmarks of precocious involution during lactation.Semantic proximity Read ↗

PMCA1 depletion in mouse eggs amplifies calcium signaling and impacts offspring growthSemantic proximity Read ↗

Characterization of the deafwaddler mutant of the rat plasma membrane calcium-ATPase 2.Semantic proximity Read ↗

The calcium pump PMCA4b promotes epithelial cell polarization and lumen formationSemantic proximity Read ↗

The calcium pump PMCA4b promotes epithelial cell polarization and lumen formationSemantic proximity Read ↗

Creation and phenotypic analysis of alpha-lactalbumin-deficient mice.Semantic proximity Read ↗

Mice carrying a conditional Serca2(flox) allele for the generation of Ca(2+) handling-deficient mouse models.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.