Article
The Plasma Membrane Calcium ATPases and Their Role as Major New Players in Human Disease.
Physiological reviews - 1 Jul 2017
Stafford Nicholas, Wilson Claire, Oceandy Delvac, Neyses Ludwig, Cartwright Elizabeth J
Abstract excerpt
The Ca2+ extrusion function of the four mammalian isoforms of the plasma membrane calcium ATPases (PMCAs) is well established. There is also ever-increasing detail known of their roles in global and local Ca2+ homeostasis and intracellular Ca2+ signaling in a wide variety of cell types and tissues. It is becoming clear that the spatiotemporal patterns of expression of the PMCAs and the fact that their abundances...
Topics
- Animals
- Calcium
- Calcium Signaling
- Cell Membrane
- Disease
- Genetic Predisposition to Disease
- Genetic Variation
- Homeostasis
- Humans
- Organ Specificity
- Phenotype
- Plasma Membrane Calcium-Transporting ATPases
- Protein Conformation
- Structure-Activity Relationship