Over-expression of an endogenous milk protein gene in transgenic mice is associated with impaired mammary alveolar development and a milchlos phenotype.

doi:10.1016/0925-4773(91)90073-f

Back to search

Article

Over-expression of an endogenous milk protein gene in transgenic mice is associated with impaired mammary alveolar development and a milchlos phenotype.

Mechanisms of development - 1 Dec 1991

Burdon T, Wall R J, Shamay A, Smith G H, Hennighausen L

Abstract excerpt

The whey acidic protein (WAP) gene is expressed in mammary epithelial cells at late pregnancy and throughout lactation. We have generated transgenic mice in which a mouse WAP transgene is expressed precociously in pregnancy. From 13 founder mice bearing WAP transgenes, two female founders and the...

Topics

Animals
Cell Differentiation
Female
Gene Expression Regulation
Male
Mammary Glands, Animal
Mice
Mice, Transgenic
Milk Proteins
Pedigree
Phenotype
Pregnancy

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.