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Article

Impaired alveologenesis and maintenance of secretory mammary epithelial cells in Jak2 conditional knockout mice.

Molecular and cellular biology - 1 Jun 2004

Wagner Kay-Uwe, Krempler Andrea, Triplett Aleata A, Qi Yongyue, George Nicholas M, Zhu Jianqiong, Rui Hallgeir

Abstract excerpt

Jak2 is a hormone-receptor-coupled kinase that mediates the tyrosine phosphorylation and activation of signal transducers and activators of transcription (Stat). The biological relevance of Jak2-Stat signaling in hormone-responsive adult tissues is difficult to investigate since Jak2 deficiency leads to embryonic lethality. We generated Jak2 conditional knockout mice to study essential functions of Jak2 during...

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Topics

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Share to Janus Kinase 2
Share to Lactation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mammary Glands, Animal

Share to Milk Proteins

Share to Prolactin

Share to Protein-Tyrosine Kinases

Share to Receptors, Prolactin

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Source

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Identifiers

PMID: 15169911
DOI: 10.1128/MCB.24.12.5510-5520.2004
PMCID: PMC419899

Genes

PRL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Impaired alveologenesis and maintenance of secretory mammary epithelial cells in Jak2 conditional knockout mice.PMID 15169911Read ↗

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STAT5B SH2 variants disrupt mammary enhancers and the stability of genetic programs during pregnancySemantic proximity Read ↗

Generation of a conditional knockout allele for the <i>Janus kinase 2</i> (<i>Jak2</i>) gene in miceSemantic proximity Read ↗

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