Article
Ectopic TGF beta 1 expression in the secretory mammary epithelium induces early senescence of the epithelial stem cell population.
Developmental biology - 1 Mar 1995
Kordon E C, McKnight R A, Jhappan C, Hennighausen L, Merlino G, Smith G H
Abstract excerpt
An important feature of the mammary gland is the regenerative capacity of its epithelium which is demonstrated upon successive cycles of lactation and involution. Pregnant mice expressing a whey-acidic protein (WAP) promoter-driven transforming growth factor-beta 1 (TGF beta 1) cDNA are unable either to generate a secretory mammary epithelium or to lactate. Here we investigate whether ectopic TGF beta 1 induces...
Topics
- Animals
- Apoptosis
- Cells, Cultured
- Cellular Senescence
- Epithelial Cells
- Epithelium
- Female
- Lactation
- Mammary Glands, Animal
- Mice
- Mice, Transgenic