Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ectopic TGF beta 1 expression in the secretory mammary epithelium induces early senescence of the epithelial stem cell population.

Developmental biology - 1 Mar 1995

Kordon E C, McKnight R A, Jhappan C, Hennighausen L, Merlino G, Smith G H

Abstract excerpt

An important feature of the mammary gland is the regenerative capacity of its epithelium which is demonstrated upon successive cycles of lactation and involution. Pregnant mice expressing a whey-acidic protein (WAP) promoter-driven transforming growth factor-beta 1 (TGF beta 1) cDNA are unable either to generate a secretory mammary epithelium or to lactate. Here we investigate whether ectopic TGF beta 1 induces...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Cells, Cultured

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epithelium

Share to Mice, Transgenic

Share to Phenotype

Share to Pregnancy

Share to Promoter Regions, Genetic

Source

Identifiers

PMID: 7883078
DOI: 10.1006/dbio.1995.1060

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ectopic TGF beta 1 expression in the secretory mammary epithelium induces early senescence of the epithelial stem cell population.PMID 7883078Read ↗

TGFbeta1 and TGFalpha contrarily affect alveolar survival and tumorigenesis in mouse mammary epithelium.Semantic proximity Read ↗

Impairment of mammary lobular development induced by expression of TGFbeta1 under the control of WAP promoter does not suppress tumorigenesis in MMTV-infected transgenic mice.Semantic proximity Read ↗

Mammary stem cell repertoire: new insights in aging epithelial populations.Semantic proximity Read ↗

Evidence for a multipotent mammary progenitor with pregnancy-specific activity.Semantic proximity Read ↗

Beta1 integrin deletion from the basal compartment of the mammary epithelium affects stem cells.Semantic proximity Read ↗

Deciphering the Mammary Epithelial Cell HierarchySemantic proximity Read ↗

Comparative Aspects of Mammary Gland Development and HomeostasisSemantic proximity Read ↗

Regulation of epithelial cell turnover and macrophage phenotype by epithelial cell-derived transforming growth factor beta1 in the mammary gland.Semantic proximity Read ↗

Adenovirus-Cre-mediated recombination in mammary epithelial early progenitor cells.Semantic proximity Read ↗

Lineage Tracing in the Mammary Gland Using Cre/lox Technology and Fluorescent Reporter Alleles.Semantic proximity Read ↗

Analysis of Mammary Gland Phenotypes by Transplantation of the Genetically Marked Mammary Epithelium.Semantic proximity Read ↗

Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.