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Article

Transgenic mice expressing recombinant human protein C exhibit defects in lactation and impaired mammary gland development.

Transgenic research - 1 Jun 2003

Palmer Carol A, Lubon Henryk, McManaman James L

Abstract excerpt

To determine if the production of recombinant human protein C (rHPC) could be increased in milk, we created two lines of mice homozygous for the mouse whey acidic protein (WAP)/human protein C (HPC) transgene. Females of both lines had normal growth, activity and fertility, but failed to lactate normally and were unable to raise litters. Histological analyses of mammary glands from lactating homozygous females...

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Source

Identifiers

PMID: 12779117
DOI: 10.1023/a:1023398926763

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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