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Article

The Drosophila insulator proteins CTCF and CP190 link enhancer blocking to body patterning.

The EMBO journal - 3 Oct 2007

Mohan Man, Bartkuhn Marek, Herold Martin, Philippen Angela, Heinl Nina, Bardenhagen Imke, Leers Joerg, White Robert A H, Renkawitz-Pohl Renate, Saumweber Harald, Renkawitz Rainer

Abstract excerpt

Insulator sequences guide the function of distantly located enhancer elements to the appropriate target genes by blocking inappropriate interactions. In Drosophila, five different insulator binding proteins have been identified, Zw5, BEAF-32, GAGA factor, Su(Hw) and dCTCF. Only dCTCF has a known conserved counterpart in vertebrates. Here we find that the structurally related factors dCTCF and Su(Hw) have distinct...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17805343
DOI: 10.1038/sj.emboj.7601851
PMCID: PMC2230845

Genes

CTCF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Drosophila insulator proteins CTCF and CP190 link enhancer blocking to body patterning.PMID 17805343Read ↗

Coordinated control of dCTCF and gypsy chromatin insulators in Drosophila.Semantic proximity Read ↗

Distinct Roles of Chromatin Insulator Proteins in Control of the Drosophila Bithorax Complex.Semantic proximity Read ↗

Functional role of dimerization and CP190 interacting domains of CTCF protein in Drosophila melanogaster.Semantic proximity Read ↗

Cooperation between architectural C2H2 proteins in CP190 recruitment to Drosophila regulatory elements.Semantic proximity Read ↗

Interactions between BTB domain of CP190 and two adjacent regions in Su(Hw) are required for the insulator complex formation.Semantic proximity Read ↗

The role of insulators and transcription in 3D chromatin organisation of fliesSemantic proximity Read ↗

Multiple interactions are involved in a highly specific association of the Mod(mdg4)-67.2 isoform with the Su(Hw) sites in Drosophila.Semantic proximity Read ↗

The centrosomal protein CP190 is a component of the gypsy chromatin insulator.Semantic proximity Read ↗

Study of the in Vivo Functional Role of Mutations in the BTB Domain of the CP190 Protein of Drosophila melanogaster.Semantic proximity Read ↗

The combined action of CTCF and its testis-specific paralog BORIS is essential for spermatogenesisSemantic proximity Read ↗

HIPP1 stabilizes the interaction between CP190 and Su(Hw) in the Drosophila insulator complex.Semantic proximity Read ↗

The Ubx Polycomb response element bypasses an unpaired Fab-8 insulator via cis transvection in Drosophila.Semantic proximity Read ↗

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