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Article

Variants within STAT genes reveal association with anticitrullinated protein antibody-negative rheumatoid arthritis in 2 European populations.

The Journal of rheumatology - 1 Aug 2012

Seddighzadeh Maria, Gonzalez Antonio, Ding Bo, Ferreiro-Iglesias Aida, Gomez-Reino Juan J, Klareskog Lars, Alfredsson Lars, Dunussi-Joannopoulos Kyri, Clark James D, Padyukov Leonid

Abstract excerpt

OBJECTIVE: STAT3 and 4 are, among other factors, critical for the interleukin 12 (IL-12)-mediated Th1 response, for transfer of IL-23 signals, and for survival and expansion of Th17 cells. We investigated the association of STAT3 and STAT4 polymorphisms with serologically distinct subgroups of rheumatoid arthritis (RA). METHODS: A total of 41 single-nucleotide polymorphisms (SNP) within STAT3 and STAT1-STAT4 loci...

Read the complete abstract on PubMed

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Share to Arthritis, Rheumatoid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Frequency

Share to Genetic Predisposition to Disease

Share to Peptides, Cyclic

Share to Polymorphism, Genetic

Share to STAT Transcription Factors

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Source

Identifiers

PMID: 22753649
DOI: 10.3899/jrheum.111284

Genes

STAT3
STAT4
STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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