Association of the STAT4 gene with increased susceptibility for some immune-mediated diseases.

doi:10.1002/art.23792

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Article

Association of the STAT4 gene with increased susceptibility for some immune-mediated diseases.

Arthritis and rheumatism - 1 Sept 2008

Martínez A, Varadé J, Márquez A, Cénit M C, Espino L, Perdigones N, Santiago J L, Fernández-Arquero M, de la Calle H, Arroyo R, Mendoza J L, Fernández-Gutiérrez B, de la Concha E G, Urcelay E

Abstract excerpt

OBJECTIVE: The STAT4 gene encodes a transcription factor involved in the signaling pathways of several cytokines, including interleukin-12 (IL-12), the type I interferons, and IL-23. Recently, the association of a STAT4 haplotype marked by rs7574865 with rheumatoid arthritis (RA) and systemic lupus erythematosus was reported. The aim of this study was to investigate the role of this STAT4 tagging polymorphism in...

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PMID: 18759272
DOI: 10.1002/art.23792

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STAT4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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