Article
Immunogenetics of rheumatoid arthritis: Understanding functional implications.
Journal of autoimmunity - 1 Nov 2015
Messemaker Tobias C, Huizinga Tom W, Kurreeman Fina
Abstract excerpt
The last decade has seen a dramatic technological revolution. The characterisation of the majority of the common variations in our genetic code in 2003 precipitated the discovery of the genetic risk factors predisposing to Rheumatoid Arthritis development and progression. Prior to 2007, only a handful of genetic risk factors had been identified, HLA, PTPN22 and CTLA4. Since then, over 100 genetic risk loci have...
Topics
- Animals
- Arthritis, Rheumatoid
- Autoimmunity
- Gene Expression Regulation
- Gene Regulatory Networks
- Genetic Loci
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- HLA Antigens
- Humans
- Immunogenetics