Article
The genetics of rheumatoid arthritis.
Rheumatology (Oxford, England) - 1 Oct 2020
Dedmon Laura E
Abstract excerpt
RA is a chronic systemic inflammatory disease that primarily affects the small joints of the hands and feet, and results in a mean reduction in life expectancy of 3-10 years. RA is a multigene disorder with a substantial genetic component and a heritability estimate of 60%. Large-scale Genome-Wide Association Studies (GWAS) and meta-analyses have revealed common disease-associated variants in the population that...
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