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Article

AID-induced remodeling of immunoglobulin genes and B cell fate.

Oncotarget - 15 Mar 2014

Laffleur Brice, Denis-Lagache Nicolas, Péron Sophie, Sirac Christophe, Moreau Jeanne, Cogné Michel

Abstract excerpt

Survival and phenotype of normal and malignant B lymphocytes are critically dependent on constitutive signals by the B cell receptor (BCR) for antigen. In addition, either antigen ligation of the BCR or various mitogenic stimuli result in B cell activation and induction of activation-induced deaminase (AID). AID activity can in turn mediate somatic hypermutation (SHM) of immunoglobulin (Ig) V regions and also...

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Topics

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Share to AICDA (Activation-Induced Cytidine Deaminase)
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Immunoglobulin Class Switching

Share to Immunoglobulin Variable Region

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Share to Receptors, Antigen, B-Cell

Share to Somatic Hypermutation, Immunoglobulin

Source

Open in PubMed Open full text

Identifiers

PMID: 24851241
DOI: 10.18632/oncotarget.1546
PMCID: PMC4012742

Genes

BCR
LSR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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