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Article

Role for the first SH3 domain of p67phox in activation of superoxide-producing NADPH oxidases.

Biochemical and biophysical research communications - 6 Feb 2009

Maehara Yuichi, Miyano Kei, Sumimoto Hideki

Abstract excerpt

The membrane-bound NADPH oxidase in phagocytes, gp91(phox) (a.k.a. Nox2), produces superoxide, a precursor of microbicidal oxidants, thereby playing a crucial role in host defense. Activation of gp91(phox)/Nox2 requires assembly with the cytosolic proteins p67(phox) and p47(phox), each containing two SH3 domains. Although the C-terminal SH3 domain of p67(phox) is responsible for binding to p47(phox), little is...

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Identifiers

PMID: 19116138
DOI: 10.1016/j.bbrc.2008.12.112

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Role for the first SH3 domain of p67phox in activation of superoxide-producing NADPH oxidases.PMID 19116138Read ↗

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