Article
The Rac target NADPH oxidase p67phox interacts preferentially with Rac2 rather than Rac1.
The Journal of biological chemistry - 5 Jan 1996
Dorseuil O, Reibel L, Bokoch G M, Camonis J, Gacon G
Abstract excerpt
NADPH oxidase is a plasma membrane enzyme of phagocytes generating superoxide anions which serve as bactericidal agents. Activation of this multimolecular enzyme minimally requires assembly at the membrane with flavocytochrome b558 of cytosolic components p47phox, p67phox, and Rac proteins. Rac1 and Rac2 are 92% homologous cytosolic small GTPase proteins. Both Rac1 and Rac2 have been implicated with NADPH oxidase...
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