Article
Megabase deletions of gene deserts result in viable mice.
Nature - 21 Oct 2004
Nóbrega Marcelo A, Zhu Yiwen, Plajzer-Frick Ingrid, Afzal Veena, Rubin Edward M
Abstract excerpt
The functional importance of the roughly 98% of mammalian genomes not corresponding to protein coding sequences remains largely undetermined. Here we show that some large-scale deletions of the non-coding DNA referred to as gene deserts can be well tolerated by an organism. We deleted two large non-coding intervals, 1,511 kilobases and 845 kilobases in length, from the mouse genome. Viable mice homozygous for the...
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