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Article

From mouse to human: evolutionary genomics analysis of human orthologs of essential genes.

PLoS genetics - 1 May 2013

Georgi Benjamin, Voight Benjamin F, Bućan Maja

Abstract excerpt

Understanding the core set of genes that are necessary for basic developmental functions is one of the central goals in biology. Studies in model organisms identified a significant fraction of essential genes through the analysis of null-mutations that lead to lethality. Recent large-scale next-generation sequencing efforts have provided unprecedented data on genetic variation in human. However, evolutionary and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23675308
DOI: 10.1371/journal.pgen.1003484
PMCID: PMC3649967

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