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Article

Mammalian ultraconserved elements are strongly depleted among segmental duplications and copy number variants.

Nature genetics - 1 Oct 2006

Derti Adnan, Roth Frederick P, Church George M, Wu C-ting

Abstract excerpt

An earlier search in the human, mouse and rat genomes for sequences that are 100% conserved in orthologous segments and > or = 200 bp in length identified 481 distinct sequences. These human-mouse-rat sequences, which represent ultraconserved elements (UCEs), are believed to be important for functions involving DNA binding, RNA processing and the regulation of transcription and development. In vivo and additional...

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PMID: 16998490
DOI: 10.1038/ng1888

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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