Article
Hmga1 null mice are less susceptible to chemically induced skin carcinogenesis.
European journal of cancer (Oxford, England : 1990) - 1 Jan 2008
Visone Rosa, Iuliano Rodolfo, Palmieri Dario, Server Ilter Nurettin, Chiappetta Gennaro, De Martino Ivana, Fedele Monica, Costinean Stefan, Oberyszyn Tatiana M, Kusewitt Donna F, Croce Carlo M, Fusco Alfredo
Abstract excerpt
The HMGA1 proteins have a critical role in the process of carcinogenesis. They are overexpressed in most human malignant neoplasias, and the inhibition of their expression has been shown to prevent cell transformation and results in malignant cell death. To determine whether HMGA1 proteins are also required for in vivo carcinogenesis, we compared the tumour susceptibility of mice wild-type or knockout for the...
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