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Article

G beta gamma counteracts G alpha(q) signaling upon alpha(1)-adrenergic receptor stimulation.

Biochemical and biophysical research communications - 8 Mar 2002

Nishida Motohiro, Takagahara Shuichi, Maruyama Yoshiko, Sugimoto Yoshiyuki, Nagao Taku, Kurose Hitoshi

Abstract excerpt

In rat neonatal myocytes, a constitutively active G alpha(q) causes cellular injury and apoptosis. However, stimulation of the alpha(1)-adrenergic receptor, one of the G(q) protein-coupled receptors, with phenylephrine for 48 h causes little cellular injury and apoptosis. Expression of the G beta gamma-sequestering peptide beta ARK-ct increases the phenylephrine-induced cardiac injury, indicating that G beta...

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Source

Identifiers

PMID: 11866464
DOI: 10.1006/bbrc.2002.6553

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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