Article
Apoptotic signaling through the beta -adrenergic receptor. A new Gs effector pathway.
The Journal of biological chemistry - 7 Jul 2000
Gu C, Ma Y C, Benjamin J, Littman D, Chao M V, Huang X Y
Abstract excerpt
Stimulation of beta-adrenergic receptor normally results in signaling by the heterotrimeric G protein G(s), leading to the activation of adenylyl cyclase, production of cAMP, and activation of cAMP-dependent protein kinase (PKA). Here we report that cell death of thymocytes can be induced after stimulation of beta-adrenergic receptor, or by addition of exogenous cAMP. Apoptotic cell death in both cases was...
Topics
- Animals
- Apoptosis
- Cell Survival
- Cyclic AMP
- Cyclic AMP-Dependent Protein Kinases
- Flow Cytometry
- GTP-Binding Proteins
- In Situ Nick-End Labeling
- Isoproterenol
- Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
- Lymphoma
- Mice
- Mutation
- Receptors, Adrenergic, beta
- Signal Transduction
- T-Lymphocytes
- Tumor Cells, Cultured