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Article

Apoptotic signaling through the beta -adrenergic receptor. A new Gs effector pathway.

The Journal of biological chemistry - 7 Jul 2000

Gu C, Ma Y C, Benjamin J, Littman D, Chao M V, Huang X Y

Abstract excerpt

Stimulation of beta-adrenergic receptor normally results in signaling by the heterotrimeric G protein G(s), leading to the activation of adenylyl cyclase, production of cAMP, and activation of cAMP-dependent protein kinase (PKA). Here we report that cell death of thymocytes can be induced after stimulation of beta-adrenergic receptor, or by addition of exogenous cAMP. Apoptotic cell death in both cases was...

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PMID: 10767282
DOI: 10.1074/jbc.M000152200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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