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Article

High incidence of epithelial cancers in mice deficient for DNA polymerase delta proofreading.

Proceedings of the National Academy of Sciences of the United States of America - 26 Nov 2002

Goldsby Robert E, Hays Laura E, Chen Xin, Olmsted Elise A, Slayton William B, Spangrude Gerry J, Preston Bradley D

Abstract excerpt

Mutations are a hallmark of cancer. Normal cells minimize spontaneous mutations through the combined actions of polymerase base selectivity, 3' --> 5' exonucleolytic proofreading, mismatch correction, and DNA damage repair. To determine the consequences of defective proofreading in mammals, we created mice with a point mutation (D400A) in the proofreading domain of DNA polymerase delta (poldelta, encoded by the...

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Share to Carcinoma, Squamous Cell
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to DNA Polymerase III

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Share to Neoplasms, Experimental

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Source

Open in PubMed Open full text

Identifiers

PMID: 12429860
DOI: 10.1073/pnas.232340999
PMCID: PMC137756

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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